Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
ZAP-70 methylation status is associated with ZAP-70 expression status in chronic lymphocytic leukemia.
BACKGROUND AND OBJECTIVES ZAP-70 expression is a recognized prognostic marker in chronic lymphocytic leukemia (CLL). The aim of this study was to analyze whether the methylation status of the ZAP-70 gene is associated with expression of the ZAP-70 protein. DESIGN AND METHODS Patients with CLL (n=87), acute lymphoblastic leukemia (n=13), mantle cell leukemia (n=13) and splenic marginal zone ly...
متن کاملModification of immunocytochemical ZAP-70 assay for potential clinical application in B-cell chronic lymphocytic leukemia.
The ZAP-70 protein is a member of the Syk/ZAP protein tyrosine kinase family, normally expressed in T cells and NK cells but not found in normal, mature B cells. The protein plays a critical role in the initiation of T-cell signaling. Leukemic cells from patients with B-cell chronic lymphocytic leukemia (B-CLL) that expressed nonmutated immunoglobulin V genes were found to express levels of ZAP...
متن کاملMore ZAP for chronic lymphocytic leukemia (CLL).
Antigen stimulation of the leukemic clone is increasingly implicated in the pathogenesis of CLL. Chen and colleagues provide evidence that expression of ZAP-70 in CLL B cells renders IgM signaling more effective and thereby could contribute to the more rapidly progressive clinical course of ZAP-70-positive CLL.
متن کاملOptimization of flow cytometric measurement of ZAP-70 in chronic lymphocytic leukemia.
BACKGROUND The goal of this study was to optimize a cell staining procedure for flow cytometric detection of zeta-chain associated protein-70 (ZAP-70). Our specific objectives were to improve antibody selection criteria, identify a cell permeabilization procedure better tailored to ZAP-70 analysis, as well as to establish objective criteria to control antigen stability. METHODS Sequentially t...
متن کاملClinical Significance of ZAP-70 Protein Expression in B-cell Chronic Lymphocytic Leukemia Short title: ZAP-70 and prognosis in B-CLL
Prepublished online April 6, 2006; Amadori Gattei, Paolo de Fabritiis, Maria Cantonetti, Francesco Lo Coco, Domenico Del Principe and Sergio Ottaviani, Paola Panetta, Antonio Bruno, Riccardo Bomben, Giovanna Suppo, Massimo Degan, Valter Licia Antonella Zucchetto, Rita Marini, Pasquale Niscola, Maria Antonietta Irno Consalvo, Carla Mazzone, Maria Ilaria Del Principe, Giovanni Del Poeta, Francesc...
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ژورنال
عنوان ژورنال: Cytometry Part B: Clinical Cytometry
سال: 2006
ISSN: 1552-4949,1552-4957
DOI: 10.1002/cyto.b.20131